Precision prevention: biological mechanisms of response variation (invite-only)

Precision prevention: biological mechanisms of response variation is an invite-only funding opportunity to support interventional human studies that generate mechanistic evidence about variation in response to biomedical prevention interventions. Projects must include experimental interventions or challenges in humans and test a mechanistic hypothesis to inform targeting and effectiveness of prevention strategies. The full economic cost of a project can be up to £5 million over up to five years, with MRC funding 80% of the project's full economic cost.

Research grant funding covering 80% of full economic costs up to a project FEC limit of £5 million; project duration funding for up to five years; eligibility support and potential contracts extension for applicants without current contracts.

Applications must be submitted by an eligible research organisation; the applicant must be employed by an eligible research organisation, direct the project and be actively engaged in the work, and be part of a team invited to apply after submitting a mandatory expression of interest. International researchers may participate as project co-lead (international), but the lead must be an eligible UK organisation.

Mandatory expression of interest (EOI) submission followed by invitation to submit a full application; lead applicant must be invited after a successful EOI; applications are submitted via the UKRI funding service.